FEATURED POPULAR SCIENCE WRITING
Swallow the Micro-Robot | NEO.LIFE | December 16, 2021
What Do Neurons and Snowflakes Have to Teach Us About AI? | NEO.LIFE | November 18, 2021
Is Your Exoskeleton Ready for Primetime? | NEO.LIFE | October 28, 2021
Shooting for Longevity and the Stars | NEO.LIFE | October 14, 2021
Enabling Scientific Discovery and Healthcare with Biobanks | GEN | November 3, 2020
Expanding the CRISPR Toolbox | GEN | March 1, 2020
June Lab Delivers CRISPR Safety Message in Cancer Clinical Trial | GEN |February 6, 2020
How to Use CRISPR for Site-Specific Epigenetic Editing in the Nervous System | GEN | November 13, 2019
How To Synthesize Stable Lifeforms For The Long Run | Medium | September 05, 2019
Is Sexual Orientation Encoded In Our DNA? | Medium | August 29, 2019
A New Way to Detect Parkinson’s—by Smell | Scientific American | April 10, 2019
The One Change That Boosts a High School’s Academic Performance | Scientific American | February 12, 2019
A New Connection between the Gut and the Brain | Scientific American | December 5, 2018
How Exercise Might “Clean” the Alzheimer’s Brain | Scientific American | October 16, 2018
COMPANY PROFILES
From Junk to Treasure: Syros Pharmaceuticals Mines Non-Coding DNA to Treat Disease | GEN Edge | October 12, 2021
Pardes Biosciences Advances Oral Antiviral Drug for SARS-CoV-2 Infections | GEN Edge | October 5, 2021
Go Your Own Way: Vector Laboratories Completes $124 Million Buyout and Initiates Acquisition Strategy | GEN Edge | October 1, 2021
Needles and Pills: Rani Therapeutics Is Making Encapsulated Oral Biologics | GEN Edge | September 7, 2021
I Can See Clearly Now: Seer Creates a Transformative View of the Protein Panorama | GEN Edge | August 18, 2021
Creating a Clinical Crystal Ball: SOPHiA Genetics is Democratizing Data-Driven Medicine | GEN Edge | August 9, 2021
The Upregulation Revolution: CAMP4’s Climb to Reach Untouched Diseases by Dialing Up Gene Expression | GEN Edge | July 27, 2021
Breaker of Chains: Karuna Therapeutics Challenges Antipsychotic Drug Barrier | GEN Edge | July 22, 2021
By Decoding Patient Drug Responses, Scipher Medicine Tackles Wasteful Healthcare Spending | GEN Edge | July 20, 2021
We Have Lift Off: Codiak BioSciences Bears Down with Exosomes as a Therapeutic Modality | GEN Edge | June 10, 2021
Designer Genes: Synlogic Is Crafting Living Therapeutics Programmed to Treat Disease | GEN Edge | 10, 2021
One in a Million: Homology Medicines Targets New Approach for Rare Genetic Diseases | GEN Edge | June 9, 2021
Heavyweight Division: Arvinas Paves the Way for Therapeutics That Degrade Disease-Related Proteins | GEN Edge | May 21, 2021
Celularity: Productizing Placental-Derived Stem Cells for Any Patient | GEN Edge | April 28, 2021
A Ruby in the Rough: Rubius Therapeutics Transforms Red Blood Cells into Cellular Medicines | GEN Edge | April 22, 2021
Let There Be Light: GreenLight Strives for Global RNA Equity to Solve Health and Agricultural Problems | GEN Edge | April 15, 2021
It’s a tRNA World: How aTyr Transformed tRNA Synthetases into Clinical Stage Medicines | GEN Edge | March 23, 2021
Shooting the Messenger: Locanabio Writes a New Script for RNA Diseases | GEN Edge | January 7, 2021
Alexa, Make Me a Protein: Denovium’s AI Reimagines De Novo Proteins | GEN Edge | December 22, 2021
23 Trillion and Me: Persephone Biosciences Harnesses the Gut Microbiome to Treat Disease | GEN Edge | December 9, 2020
X and Y: Synthorx Expands the Genetic Code to Create Optimized Biologics | GEN Edge | November 19, 2020
Can Encodia Become the Illumina of Proteomics? | GEN Edge | November 5, 2020
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Research Publications
Zhang Y, Li T, Preissl S, Amaral ML, Grinstein JD, Farah EN, Destici E, Qiu Y, Hu R, Lee AY, Chee S, Ma K, Ye Z, Zhu Q, Huang H, Fang R, Yu L, Izpisua Belmonte JC, Wu J, Evans SM, Chi NC, Ren B. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nat Genet. 2019 Sep;51(9):1380-1388. doi: 10.1038/s41588-019-0479-7.
Veevers J, Farah EN, Corselli M, Witty AD, Palomares K, Vidal JG, Emre N, Carson CT, Ouyang K, Liu C, van Vliet P, Zhu M, Hegarty JM, Deacon DC, Grinstein JD, Dirschinger RJ, Frazer KA, Adler ED, Knowlton KU, Chi NC, Martin JC, Chen J, Evans SM. Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells. Stem Cell Reports. 2018. doi: 10.1016/j.stemcr.2018.07.007.
Panopoulos AD, D’Antonio M, Arias AD, Benaglio P, DeBoever C, Williams R, Garcia M, Nelson B, Harismendy O, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Jepsen K, McGarry T, Matsui H, Reyna J, Aguirre A, Rao F, O’Connor DT, Chi NC, Goldstein LS, Izpisua Belmonte JC, Berggren WT, Adler E, D’Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A systematically derived resource of iPSC lines from 222 individuals for use in examining how genetic variation affects molecular and physiological traits across a variety of cell types. Stem Cell Reports. 2017. doi: 10.1016/j.stemcr.2017.03.012.
Han P, Bloomekatz J, Ren J, Zhang R, Grinstein JD, Zhao L, Burns CG, Burns CE, Anderson RM, Chi NC. Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 2016. doi: 10.1038/nature18310.
Lacombe J, Hanley O, Jung H, Philippidou P, Surmeli G, Grinstein JD, Dasen JS. Dev. Cell. 2013. Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons. PLoS Genet. 2013. doi: 10.1371/journal.pgen.1003184.
Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 2011. doi: 10.1016/j.cell.2011.08.054.
Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein JD, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS. Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 2010. doi: 10.1016/j.neuron.2010.08.008.
Jonathan D. Grinstein, PhD 