Genetic Engineering & Biotechnology News (GEN)
Enabling Scientific Discovery and Healthcare with Biobanks | November 3, 2020
Expanding the CRISPR Toolbox | March 1, 2020
June Lab Delivers CRISPR Safety Message in Cancer Clinical Trial | February 6, 2020
How to Use CRISPR for Site-Specific Epigenetic Editing in the Nervous System | November 13, 2019
GEN Edge
The Upregulation Revolution: CAMP4’s Climb to Reach Untouched Diseases by Dialing Up Gene Expression | July 27, 2021
Breaker of Chains: Karuna Therapeutics Challenges Antipsychotic Drug Barrier | July 22, 2021
By Decoding Patient Drug Responses, Scipher Medicine Tackles Wasteful Healthcare Spending | July 20, 2021
We Have Lift Off: Codiak BioSciences Bears Down with Exosomes as a Therapeutic Modality | June 10, 2021
Designer Genes: Synlogic Is Crafting Living Therapeutics Programmed to Treat Disease | June 10, 2021
One in a Million: Homology Medicines Targets New Approach for Rare Genetic Diseases | June 9, 2021
Heavyweight Division: Arvinas Paves the Way for Therapeutics That Degrade Disease-Related Proteins | May 21, 2021
Celularity: Productizing Placental-Derived Stem Cells for Any Patient | April 28, 2021
A Ruby in the Rough: Rubius Therapeutics Transforms Red Blood Cells into Cellular Medicines | April 22, 2021
Let There Be Light: GreenLight Strives for Global RNA Equity to Solve Health and Agricultural Problems | April 15, 2021
It’s a tRNA World: How aTyr Transformed tRNA Synthetases into Clinical Stage Medicines | March 23, 2021
Shooting the Messenger: Locanabio Writes a New Script for RNA Diseases | January 7, 2021
Alexa, Make Me a Protein: Denovium’s AI Reimagines De Novo Proteins | December 22, 2021
23 Trillion and Me: Persephone Biosciences Harnesses the Gut Microbiome to Treat Disease | December 9, 2020
X and Y: Synthorx Expands the Genetic Code to Create Optimized Biologics | November 19, 2020
Can Encodia Become the Illumina of Proteomics? | November 5, 2020
Medium
How To Synthesize Stable Lifeforms For The Long Run | September 05, 2019
Is Sexual Orientation Encoded In Our DNA? | August 29, 2019
Neuroleadership Institute
4 Ways to Honor (or Overwhelm) Your Employees’ Cognitive Capacity | June 9, 2020
Cultivate Your Growth Mindset to Thrive Through Crisis | May 20, 2020
3 Psychological Habits to Deliver What Matters During a Crisis | May 7, 2020
How to Be Optimistic and Realistic During the COVID-19 Pandemic | April 24, 2020
Focusing the Public Sector in a Telework World | March 24, 2020
What the Challenger Disaster Teaches Us About Speaking Up In A New Era Of Spaceflight| February 27, 2020
Science 101
Mindfulness meditation mends mild cognitive impairment | November 27, 2019
This is your brain on Black Friday | November 26, 2019
The race to stop cat allergies | October 29, 2019
AI learns to solve Rubik’s Cube without human help | October 29, 2019
Smartphones and Fitbits can spot loneliness in its tracks | October 2, 2019
Human sexes use their whole genomes distinctively | August 28, 2019
Athletes make performance enhancing gut microbes | August 13, 2019
Brain stimulation revives working memory in older adults | July 18, 2019
Becoming plastic people: a survey on microplastics consumption | July 18, 2019
Spores squash malaria mosquitos with spider venom | June 13, 2019
Seeing the twilight zone in technicolor through deep sea fish eyes | June 6, 2019
Seaworm species recently evolved the ability to regenerate heads — brains included | June 3, 2019
Sounding out ear infections with smartphones and paper | May 28, 2019
How to artificially implant a memory, ‘Inception’-style | May 20, 2019
The brain’s unique ‘drain system’ could flush Alzheimer’s | May 13, 2019
Scientific American
A New Way to Detect Parkinson’s—by Smell | April 10, 2019
The One Change That Boosts a High School’s Academic Performance | February 12, 2019
A New Connection between the Gut and the Brain | December 5, 2018
How Exercise Might “Clean” the Alzheimer’s Brain | October 16, 2018
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Research Publications
Zhang Y, Li T, Preissl S, Amaral ML, Grinstein JD, Farah EN, Destici E, Qiu Y, Hu R, Lee AY, Chee S, Ma K, Ye Z, Zhu Q, Huang H, Fang R, Yu L, Izpisua Belmonte JC, Wu J, Evans SM, Chi NC, Ren B. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nat Genet. 2019 Sep;51(9):1380-1388. doi: 10.1038/s41588-019-0479-7.
Veevers J, Farah EN, Corselli M, Witty AD, Palomares K, Vidal JG, Emre N, Carson CT, Ouyang K, Liu C, van Vliet P, Zhu M, Hegarty JM, Deacon DC, Grinstein JD, Dirschinger RJ, Frazer KA, Adler ED, Knowlton KU, Chi NC, Martin JC, Chen J, Evans SM. Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells. Stem Cell Reports. 2018. doi: 10.1016/j.stemcr.2018.07.007.
Panopoulos AD, D’Antonio M, Arias AD, Benaglio P, DeBoever C, Williams R, Garcia M, Nelson B, Harismendy O, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Jepsen K, McGarry T, Matsui H, Reyna J, Aguirre A, Rao F, O’Connor DT, Chi NC, Goldstein LS, Izpisua Belmonte JC, Berggren WT, Adler E, D’Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A systematically derived resource of iPSC lines from 222 individuals for use in examining how genetic variation affects molecular and physiological traits across a variety of cell types. Stem Cell Reports. 2017. doi: 10.1016/j.stemcr.2017.03.012.
Han P, Bloomekatz J, Ren J, Zhang R, Grinstein JD, Zhao L, Burns CG, Burns CE, Anderson RM, Chi NC. Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 2016. doi: 10.1038/nature18310.
Lacombe J, Hanley O, Jung H, Philippidou P, Surmeli G, Grinstein JD, Dasen JS. Dev. Cell. 2013. Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons. PLoS Genet. 2013. doi: 10.1371/journal.pgen.1003184.
Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 2011. doi: 10.1016/j.cell.2011.08.054.
Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein JD, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS. Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Neuron. 2010. doi: 10.1016/j.neuron.2010.08.008.
